M6A RIP-seq of beta-cell s from liver-specific insulin receptor knockout (LIRKO) mice

ABSTRACT: In type 2 diabetes, pancreatic beta-cells fail to compensate for the presence of insulin resistance in target tissues. Identifying and studying innovative molecular mechanisms that control the beta-cell adaptation to insulin resistance represent an interesting line of research and are necessary. N6-Methyladenosine (m6A) is the most abundant modification in mRNA and is found virtually in all mammals. Through m6A-profiling of Control and LIRKO islets we aimed to identify the m6A landscape of the successful beta-cell adaption to insulin resistance.

ORGANISM(S): Mus musculus

PROVIDER: GSE297196 | GEO | 2026/05/14

REPOSITORIES: GEO