Loss of the retinoblastoma tumor suppressor is a common event in Basal-like and Luminal B breast carcinomas

ABSTRACT: Breast cancers can be classified using whole genome expression into distinct subtypes that show differences in patient prognosis. One of these groups, the basal-like carcinomas, are poorly differentiated, highly metastatic, and genomically unstable. These tumors also contain specific genetic alterations with one example being frequent p53 mutations. The loss of the tumor suppressor gene encoded by the retinoblastoma (RB1) locus is a well-characterized occurrence in many tumor types, however, its role in breast cancer is less clear with many reports demonstrating a Loss of Heterozygosity (LOH) that does not correlate with loss of RB1 protein expression. Here we report that LOH of the RB1 locus was observed at a high frequency in basal-like and luminal B tumors. These tumors also concurr

ORGANISM(S): Homo sapiens

SUBMITTER: Jason Herschkowitz 

PROVIDER: E-GEOD-10884 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress