FGF Receptor and Wnt-1 Signaling Cooperate in Mammary Tumorigenesis

ABSTRACT: The fibroblast growth factor pathway is known to cooperate with the highly oncogenic Wnt/-catenin pathway in mouse models of breast cancer. To investigate the mechanisms involved in this cooperativity, we utilized MMTV-driven transgenic mouse lines expressing a drug-inducible model for FGF Receptor signaling (iFGFR) crossed with the previously characterized MMTV-Wnt-1 mouse model. In these bigenic mice, both iFGFR1 and iFGFR2 activation resulted in a dramatic enhancement of mammary tumorigenesis. Tumor microarray analysis identified no transcriptional enhancement of Wnt/-catenin targets, however, identified a protein translational gene signature that also correlated with elevated FGFR1 and FGFR2 expression in several human breast cancer data sets. Additionally, iFGFR1 activation

ORGANISM(S): Mus musculus

SUBMITTER: Jason Herschkowitz 

PROVIDER: E-GEOD-17916 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress