Tumor Intrinsic Subtype is Reflected in Cancer-Adjacent Benign Tissue

ABSTRACT: Introduction: Overall survival of early-stage breast cancer (BC) patients is similar for those who undergo breast conserving therapy (BCT) and mastectomy, however, 10-15% of women undergoing BCT suffer ipsilateral breast tumor recurrence. The risk of recurrence may vary with age or breast cancer subtype. Understanding the gene expression of the cancer-adjacent tissue and/or stromal response to specific tumor subtypes is important for developing clinical strategies to reduce recurrence risk. Methods: We studied gene expression data in cancer-adjacent tissue from 158 BC patients. Complementary in vitro cocultures were used to study cell-cell communication between fibroblasts and specific breast cancer subtypes. Results: Our results suggest that intrinsic tumor subtypes are reflected in histo

ORGANISM(S): Homo sapiens

SUBMITTER: Melissa Troester 

PROVIDER: E-GEOD-50939 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress