Suppression of breast tumor growth and metastasis by an engineered transcription factor

ABSTRACT: Abstract Maspin is a tumor and metastasis suppressor playing an essential role as gatekeeper of tumor progression. It is highly expressed in epithelial cells but is silenced in the onset of metastatic disease by epigenetic mechanisms. Reprogramming of Maspin epigenetic silencing offers a therapeutic potential to lock metastatic progression. Herein we have investigated the ability of the Artificial Transcription Factor 126 (ATF-126) designed to upregulate the Maspin promoter to inhibit tumor progression in pre-established breast tumors in immunodeficient mice. ATF-126 was transduced in the aggressive, mesenchymal-like and triple negative breast cancer line, MDA-MB-231. Induction of ATF expression in vivo by Doxycycline resulted in 50% reduction in tumor growth and totally abolished tumor ce

ORGANISM(S): Homo sapiens

SUBMITTER: PILAR BLANCAFORT 

PROVIDER: E-GEOD-27842 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress