Calorie Restriction Feminizes Liver Gene Expression and Alters Key Regulators of Conserved Aging Regulatory Pathways

ABSTRACT: Background: Calorie restriction (CR) is the only intervention known to extend lifespan in a wide range of organisms, including mammals. However, the mechanisms by which it regulates mammalian aging remain largely unknown and the involvement of the TOR and Sirtuin pathways (which regulate aging in lower organisms) remain controversial. Femaleness is a second phenotype generally associated with longevity but the relationship between sex-biased and CR-induced gene expression remains undetermined. Methodology/Principal Findings: We generated microarray gene expression data from livers of male mice fed high calorie or CR diets, and we find that CR significantly changes the expression of over 3,000 genes, many between 10- and 50-fold. We compare our data to the GenAge database of known aging-

ORGANISM(S): Mus musculus

SUBMITTER: preston estep 

PROVIDER: E-GEOD-11244 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress