Comparison between Borrelia burgdorferi wild type strain and cognate rpoS, rpoN and rrp2 mutants

ABSTRACT: The RpoN-RpoS alternative sigma factor pathway is essential for key adaptive responses by Borrelia burgdorferi, particularly those involved in the infection of a mammalian host. A putative response regulator, Rrp2, ostensibly is required for activation of the RpoN-dependent transcription of rpoS. However, questions remain regarding the extent to which the three major constituents of this pathway (Rrp2, RpoN, and RpoS) act interdependently. To assess the functional interplay between Rrp2, RpoN, and RpoS, we employed microarray analyses to compare gene expression levels in rrp2, rpoN, or rpoS mutants of parental strain 297. We identified 98 genes that were similarly regulated by Rrp2, RpoN and RpoS, and an additional 47 genes were determined to be likely regulated by this pathway. The s

ORGANISM(S): Borrelia burgdorferi

SUBMITTER: zhiming ouyang 

PROVIDER: E-GEOD-11284 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress