The RpoN Regulon of Escherichia coli O157:H7

ABSTRACT: There is increasing evidence to support a role for sigma factor 54 (RpoN) in the regulation of stress resistance factors and protein secretion systems important to bacterial transmission and pathogenesis. In enterohemorrhagic E. coli O157:H7, acid resistance and type III secretion are essential determinants of gastric passage and colonization. This study thus described the transcriptome of an rpoN null strain of E. coli O157:H7 (EcJR-8) to determine the influence of RpoN on virulence and stress resistance gene regulation, and further explored its contribution to glutamate-dependent acid resistance (GDAR). Inactivation of rpoN resulted in the growth phase-dependent, differential expression of 104 genes. This included type III secretion structural and regulatory genes encoded on the loc

ORGANISM(S): Escherichia coli O157:H7 str. Sakai

SUBMITTER: James Riordan 

PROVIDER: E-GEOD-17467 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress