Identification of genes regulated by gadE in E. coli O157:H7

ABSTRACT: Integrating laterally acquired virulence genes into the backbone regulatory network is important for the pathogenesis of Escherichia coli O157:H7, which has captured many virulence genes through horizontal transfer during evolution. GadE is an essential transcriptional activator of glutamate decarboxylase (GAD) system, the most efficient acid resistance mechanism in E. coli. The full contribution of GadE to the acid resistance and virulence of pathogenic E. coli O157:H7 remains largely unknown. We inactivated gadE in E. coli O157:H7 Sakai and compared global transcription profiles with that of wild type in exponential and stationary phases of growth using microarrays containing 6088 ORFs from three E. coli genomes. gadE inactivation significantly altered the expression of 60 genes independ

ORGANISM(S): Escherichia coli

SUBMITTER: Sivapriya Kailasan Vanaja 

PROVIDER: E-GEOD-13132 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress