Infection of the larval airway epithelium by Erwinia carotovora

ABSTRACT: The unsurpassed simplicity of the fruitfly’s airway epithelium, that is made of homogenous epithelial cells only, favours its use as a model to study general features and response characteristics of airway epithelia in general. All epithelial cells are able to launch an immune response as characterized by the expression of antimicrobial peptide genes. Infection induces a complex change in the expression profile of these epithelial cells. Outstanding are a priming of the immune system and the launch of a survival program, presumably to counteract infection induced apoptotic signals, which comprises the concurrent expression of known longevity genes such as dFoxo, and dThor. In regions of the airway epithelium with strong immune reactions, a complex remodelling of the airways can be observ

ORGANISM(S): Drosophila melanogaster

SUBMITTER: Thomas Roeder 

PROVIDER: E-GEOD-11444 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress