Transcription profiling of mouse Splenic DO11.10 cells ectopically expressing twist 1

ABSTRACT: The basic helix-loop-helix transcriptional repressor twist1, as an antagonist of nuclear factor κB (NF-κB)-dependent cytokine expression, is involved in the regulation of inflammation-induced immunopathology. We could show that twist1 is expressed by activated T helper (Th) 1 effector memory cells. Induction of twist1 in Th cells is dependent on NF-κB, nuclear factor of activated T cells (NFAT), and interleukin (IL)-12 signaling via signal transducer and activator of transcription (STAT) 4. Expression of twist1 is transient following T-cell receptor engagement, and increases upon repeated stimulation of Th1 cells. Imprinting for enhanced twist1 expression is characteristic of repeatedly restimulated effector memory Th cells and thus of the pathogenic memory Th cells of chronic inflammat

ORGANISM(S): Mus musculus

SUBMITTER: Joachim Grün 

PROVIDER: E-GEOD-11533 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress