Bacillus subtilis 168 cells: wild-type vs. ccpN (non polar)

ABSTRACT: Global transcriptional profiling of Bacillus subtilis cells comparing wild-type to a ccpN (yqzB) non polar mutant. Abstract of associated publication (article accepted): The transcriptional regulator CcpN of Bacillus subtilis has been recently characterized as a repressor of two gluconeogenic genes, gapB and pckA, and of a small non-coding regulatory RNA, sr1, involved in arginine catabolism. Deletion of ccpN impairs growth on glucose and strongly alters the distribution of intracellular fluxes, rerouting the main glucose catabolism from glycolysis to the pentose phosphate (PP) pathway. Using transcriptome analysis, we show that during growth on glucose, gapB and pckA are the only protein-coding genes directly repressed by CcpN. By quantifying intracellular fluxes in deletion mutants, we

ORGANISM(S): Bacillus subtilis subsp. subtilis str. 168

SUBMITTER: Thierry Doan 

PROVIDER: E-GEOD-11873 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress