Induction of 1C Aldoketoreductases and Other Drug Dose-dependent Genes Upon Acquisition of Anthracycline Resistance

ABSTRACT: Recent studies have suggested that elevated expression of aldoketoreductase (AKR) 1C1 or 1C2 in tumour cells is associated with increased resistance to DNA damaging agents such as cisplatin and doxorubicin. However, it has not been shown whether selection of tumour cells for resistance to DNA-damaging anthracyclines actually results in increased expression of AKRs and increased conversion of anthracyclines to 10-fold less toxic 13-hydroxy metabolites. It is also unclear whether the induction of aldokeoreductases is temporally correlated with the onset of anthracycline resistance and whether there is a direct relationship between the level of AKR expression or activity and the magnitude of drug resistance. Through microarray profiling of MCF-7 breast cancer cells selected for progressive

ORGANISM(S): Homo sapiens

SUBMITTER: baoqing guo 

PROVIDER: E-GEOD-12115 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress