Transcription profiling of mouse colon gene expression associated with increased colon inflammation in IL-10-/- mice inoculated with Enterococcus sp.

ABSTRACT: Inappropriate response to normal intestinal bacteria is involved in the development of Inflammatory Bowel Diseases (IBD, e.g. Crohnâ??s Disease (CD), ulcerative colitis (UC)) and variations in the host genome may mediate this process. IL-10-/- mice develop CD-like colitis mainly in the colon, in part due to inappropriate responses to normal intestinal bacteria including Enterococcus strains. Comprehensive characterization of changes in gene expression associated with the observed inflammation in the IL-10-/- mouse model has yet to be reported. Our aim was to characterize changes in colonic gene expression in IL-10-/- and C57BL/6J (C57; control) mice resulting from oral bacterial inoculation with 12 Enterococcus faecalis and faecium (EF) strains isolated from calves or poultry, complex inte

ORGANISM(S): Mus musculus

SUBMITTER: Matthew Barnett 

PROVIDER: E-GEOD-12223 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress