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Tenotomized Achilles tendons of MRL/MpJ mice show scar-mediated healing, but have superior recovery of biomechanical properties

ABSTRACT: The purpose of this project is to determine changes in proteins and signaling pathways in injured tendons of C57BL/6j and MRL/MpJ mice. The MRL.MpJ mice have been reported to have a strong repair ability compared to that of C57BL/6j mice. Identifying signaling pathways in MRL/MpJ tendons that are distinct from C57BL/6j tendons will help us understand the molecular mechanisms underlying the better healing ability of MRL/MpJ mice. The samples include normal and injured Achilles tendons 4 weeks after tenotomy surgery obtained from male and female C57BL/6j and MRL/MpJ. The Achilles injury surgery was performed at 12 weeks of age. Normal tendons were obtained age, sex and strain-matched mice without surgery. The collected normal and inured tendons were subjected to proteomics.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Tendon

SUBMITTER: Mehari Weldemariam

LAB HEAD: Maureen A.

PROVIDER: PXD057712 | Pride | 2025-05-16

REPOSITORIES: Pride

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			Action	DRS
	20230714_Motomi_Tendon_injured_uninjured_120min_500ng_sample_1.raw	Raw
	20230714_Motomi_Tendon_injured_uninjured_120min_500ng_sample_10.raw	Raw
	20230714_Motomi_Tendon_injured_uninjured_120min_500ng_sample_11.raw	Raw
	20230714_Motomi_Tendon_injured_uninjured_120min_500ng_sample_12.raw	Raw
	20230714_Motomi_Tendon_injured_uninjured_120min_500ng_sample_13.raw	Raw

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