Gene expression profiling of BRCA1-mutated breast tumors

ABSTRACT: Background: Breast cancer is a complex disease, encompassed by different clinically and molecularly stratified entities. In 2000, Perou and colleagues demonstrated that tumor phenotypic diversity correlates with differences in global gene expression patterns, which in turn reflect aspects of the biological behavior of the tumors. Gene expression profiling has distinguished sporadic breast tumor sub-classes with genetic, histopathological and clinical differences, however, little is known about the molecular classification of hereditary breast tumors. It has been recently suggested that most tumors arising in BRCA1 mutation carriers display a basal-like phenotype, with the percentages reported in different studies ranging from 44 to almost 100%. In the present study we used expression profi

ORGANISM(S): Homo sapiens

SUBMITTER: Ricardo Fernández-Ramires 

PROVIDER: E-GEOD-12350 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress