Effect of pH on Cadmium Toxicity in Escherichia coli

ABSTRACT: Metals at high concentrations can exert toxic effects on microorganisms. It has been widely reported that lowering environmental pH reduces effects of cadmium toxicity in bacteria. Understanding the effects of pH-mediated cadmium toxicity on bacteria would be useful for minimizing cadmium toxicity in the environment and gaining insight into the interactions between organic and inorganic components of life. Growth curve analysis confirmed that cadmium was less toxic to Escherichia coli at pH 5 than at pH 7 in M9 minimal salts medium. To better understand the cellular mechanisms by which lowering pH decreases cadmium toxicity, we used DNA microarrays to characterize global gene expression patterns in E. coli in response to cadmium exposure at moderately acidic (5) and neutral (7) values

ORGANISM(S): Escherichia coli str. K-12 substr. MG1655

SUBMITTER: Craig Worden 

PROVIDER: E-GEOD-12373 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress