Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of mouse MNV-1 infected and mock-infected RAW 264.7 cells.

ABSTRACT: Noroviruses have been widely recognized for their importance as causative agents of non-bacterial gastroenteritis. Mouse norovirus is the only representative of the norovirus genus, family Caliciviridae, able to grow in cell culture. The aim of this study is to describe the differences in the expression profiles of MNV-1 and mock-infected macrophages (RAW 264.7 cells), in order to better understand the response of the host cell to norovirus infection. Experiment Overall Design: This study compares two type of samples (MNV-infected and mock-infected RAW cells) in biological triplicates respectively. The MNV stock used for infection was obtained in the same cell line, and purified with a sucrose cushion in order to account for expression changes caused by virus infection only.

ORGANISM(S): Mus musculus

SUBMITTER: Karin Bok 

PROVIDER: E-GEOD-12518 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Apoptosis in murine norovirus-infected RAW264.7 cells is associated with downregulation of survivin.

Bok Karin K   Prikhodko Victor G VG   Green Kim Y KY   Sosnovtsev Stanislav V SV  

Journal of virology 20090211 8

Noroviruses (NVs) are recognized as a major cause of nonbacterial gastroenteritis in humans. Studies of the human NVs continue to be hampered by the inability to propagate them in any cell culture system. Until recently, most data concerning NV replication were derived from studies of feline calicivirus and rabbit hemorrhagic disease virus, which are cultivable members of the family Caliciviridae. From such studies, it was proposed that caliciviruses induce apoptosis to facilitate the disseminat  ...[more]

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