Dataset Information


Expression Profiles of 15(S)-HETE treated RAW 264.7 cells

ABSTRACT: Hemozoin phagocytosis results in immunomodulation. This study was designed to explore gene expression responses to 15(S)-HETE in LPS-stimulated RAW 264.7 cells. Overall design: Three biological replicates were analyzed for each treatment type. Each replicate was composed of 6 pooled wells from a 6-well plate.

INSTRUMENT(S): ABI Mouse Genome Survey Microarray

SUBMITTER: David W Wright  

PROVIDER: GSE15070 | GEO | 2009-12-17



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Differential gene expression mediated by 15-hydroxyeicosatetraenoic acid in LPS-stimulated RAW 264.7 cells.

Schrimpe Alexandra C AC   Wright David W DW  

Malaria journal 20090811

Given the immuno-modulatory activity of native haemozoin (Hz), the effects of constitutive Hz components on immune response are of interest. Recently, gene expression changes mediated by HNE and the synthetic analogue of Hz, beta-haematin (BH), were identified and implicated a significant role for lipid peroxidation products in Hz's activity. The study presented herein examines gene expression changes in response to 15(S)-hydroxyeicosatetraenoic acid (HETE) in a model macrophage cell line.LPS-st  ...[more]

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