Gene expression pattern similarity and differences between hair follicles and basal cell carcinomas

ABSTRACT: Hair follicles (HF) and BCCs can be regarded as ordered and disordered skin appendages respectively and may utilize similar molecular mechanisms of growth. We wanted to examine the similarities and differences in gene expression patterns between BCCs and HF to define common growth mechanisms and gene expression patterns that distinguish an ordered skin appendage from a disordered skin growth. Nodular BCCs (n= 8) and non-follicular skin epithelium (n=8) were obtained. Scalp hair follicle root sheath was micro dissected from between the sebaceous gland duct and the lower one third of the HF (n=7). Microarray analysis was performed using 21K cDNA arrays and selected genes were validated using qPCR and histochemistry staining. Two differentially expressed gene sets were identified by significa

ORGANISM(S): Homo sapiens

SUBMITTER: Mei Yu 

PROVIDER: E-GEOD-12542 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress