Gene Expression in Castration-Resistant C4-2 Cells after AR Knockdown

ABSTRACT: Prostate cancer is the most common, lethal malignancy in men. Although androgen withdrawal therapies are used to treat advanced disease, progression to a castration-resistant, end-stage is the usual outcome. In this study, the tested hypothesis was that the androgen receptor remains essential for the growth and viability of castration-resistant disease. Knocking down the androgen receptor in well-established tumors grown in castrated mice caused growth arrest, decreased serum PSA, and frequently regression and total eradication of tumors. Growth control of castration-resistant tumors appeared to be linked to the extent of androgen receptor knockdown, which triggers upregulation of many genes involved in apoptosis, cell cycle arrest, and inhibition of tumorigenesis and protein synthesis. Ou

ORGANISM(S): Homo sapiens

SUBMITTER: Helen Cheng 

PROVIDER: E-GEOD-13332 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress