Transcription profiling of human prefrontal cortex (BA10)

ABSTRACT: We performed the oligonucleotide microarray analysis in bipolar disorder, major depression, schizophrenia, and control subjects using postmortem prefrontal cortices provided by the Stanley Foundation Brain Collection. By comparing the gene expression profiles of similar but distinctive mental disorders, we explored the uniqueness of bipolar disorder and its similarity to other mental disorders at the molecular level. Notably, most of the altered gene expressions in each disease were not shared by one another, suggesting the molecular distinctiveness of these mental disorders. We found a tendency of downregulation of the genes encoding receptor, channels or transporters, and upregulation of the genes encoding stress response proteins or molecular chaperons in bipolar disorder. Altered expre

ORGANISM(S): Homo sapiens

SUBMITTER: Kazuya Iwamoto 

PROVIDER: E-GEOD-12654 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress