Transcription profiling of mouse GAP-43 HZ and knockout mouse barrel cortex show modifications in genes associated with synaptogenesis and barrel map formation

ABSTRACT: Mice lacking the growth associated protein, GAP-43, (KO) show multiple deficits in forebrain axon guidance and cortical cell differentiation (Donovan and McCasland, 2005). As a result, GAP-43 KO mice fail to form barrels in mouse somatosensory cortex (S1) (Maier et al., 1999). GAP-43 heterozygous (HZ) mice show abnormalities in axonal pathfinding and show larger than normal barrels in layer IV S1 due to widely branched thalamocortical afferents (TCAs). Regardless of abnormalities during early development, HZ barrels become indistinguishable from WT by postnatal day 26. One explanation for these findings is that compensatory mechanisms may be activated in GAP-43 HZ cortex. We have used mRNA microarray expression analysis to gain a more comprehensive view of genes involved in GAP-43 signalin

ORGANISM(S): Mus musculus

SUBMITTER: Frank Middleton 

PROVIDER: E-GEOD-12687 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress