Transcription profiling of mouse WT and Cav-3 knockouts on FVB/N genetic background mammary glands reveals loss of caveolin-3 induces the development of a lactogenic microenvironment

ABSTRACT: Here, we show that functional loss of a single gene is sufficient to confer constitutive milk protein production and protection against mammary tumor formation. Caveolin-3 (Cav-3), a muscle-specific caveolin-related gene, is highly expressed in striated and smooth muscle cells. We demonstrate that Cav-3 is also expressed in myoepithelial cells within the mammary gland. To determine if genetic ablation of Cav-3 expression affects adult mammary gland development, we next studied the phenotype(s) of Cav-3 (-/-) null mice. Interestingly, detailed analysis of Cav-3 (-/-) virgin mammary glands shows dramatic increases in ductal thickness, side-branching, and the development of extensive lobulo-alveolar hyperplasia, akin to the changes normally observed during pregnancy and lactation. Analysis by

ORGANISM(S): Mus musculus

SUBMITTER: Mathew Casimiro 

PROVIDER: E-GEOD-12881 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress