Transcription profiling of C. elegans L1-L2 stage nematodes wild type and four mutants (alg-1, zfp-1, rde-4, lin-35)

ABSTRACT: Expession data from L1-L2 stage nematodes (C. elegans), wild type and four mutants (alg-1, zfp-1, rde-4, lin-35). In C. elegans, a vast number of endogenous short RNAs corresponding to thousands of genes have been discovered recently. This finding suggests that these short interfering RNAs may contribute to regulation of many developmental and other signaling pathways in addition to silencing viruses and transposons. Based on this microarray analysis of gene expression in RNA interference (RNAi)-related mutants rde-4, zfp-1 and alg-1 and the Retinoblastoma (Rb) mutant lin-35, we found that a component of Dicer complex RDE-4 and a chromatin-related zinc finger protein ZFP-1, not implicated previously in endogenous RNAi, regulate overlapping sets of genes. Notably, genes a) upregulated in th

ORGANISM(S): Caenorhabditis elegans

SUBMITTER: Sebastian Hoersch 

PROVIDER: E-GEOD-13258 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress