Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Zachary Conrad Hartman
PROVIDER: E-GEOD-13274 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Hartman Zachary C ZC Wei Junping J Osada Takuya T Glass Oliver O Lei Gangjun G Yang Xiao-Yi XY Peplinski Sharon S Kim Dong-Wan DW Xia Wenle W Spector Neil N Marks Jeffrey J Barry William W Hobeika Amy A Devi Gayathri G Amalfitano Andrea A Morse Michael A MA Lyerly H Kim HK Clay Timothy M TM
Clinical cancer research : an official journal of the American Association for Cancer Research 20100223 5
<h4>Purpose</h4>Overexpression of the breast cancer oncogene HER2 correlates with poor survival. Current HER2-directed therapies confer limited clinical benefits and most patients experience progressive disease. Because refractory tumors remain strongly HER2+, vaccine approaches targeting HER2 have therapeutic potential, but wild type (wt) HER2 cannot safely be delivered in immunogenic viral vectors because it is a potent oncogene. We designed and tested several HER2 vaccines devoid of oncogenic ...[more]