Transcription profiling of mouse skin 24 hours after intradermal infection with Trypanosoma cruzi

ABSTRACT: To investigate the early host response triggered by three different strains of Trypanosoma cruzi at a local infection site, changes in host gene expression were monitored in a murine intradermal infection model using Affymetrix oligonucleotide arrays. Robust induction of IFN-stimulated genes (ISGs) was observed in excised skin 24 hours post-infection where the level of ISG induction was parasite strain-dependent with the least virulent strain triggering a muted IFN response. Infection of mice immunodepleted of IFNγ-producing cells or infection of IFNγ-deficient mice had minimal impact on the IFN response generated in T. cruzi infected mice. In contrast, infection of mice lacking the type I IFN receptor demonstrated that type I IFNs are largely responsible for the IFN response generated a

ORGANISM(S): Mus musculus

SUBMITTER: Barbara Burleigh 

PROVIDER: E-GEOD-13522 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress