Transcription profiling of rat basolateral amygdala to examine gene expression differences in nderlying fear learning in epileptogenic and control animals

ABSTRACT: Here we tested a hypothesis that epileptogenesis influences expression pattern of genes in the basolateral amygdala that are critical for fear conditioning. Whole genome molecular profiling of basolateral rat amygdala was performed to compare the transcriptome changes underlying fear learning in epileptogenic and control animals. Our analysis revealed that after acquisition of fear conditioning 26 genes were regulated differently in the basolateral amygdala of both groups. Thus, our study provides the first evidence that not only the damage to the neuronal pathways but also altered composition or activity level of molecular machinery responsible for formation of emotional memories within surviving pathways can contribute to impairment in emotional learning in epileptogenic animals. Underst

ORGANISM(S): Rattus norvegicus

SUBMITTER: Katarzyna Majak 

PROVIDER: E-GEOD-13624 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress