SAGE libraries from cell bodies and axons of NGF-differentiated sympathetic neurons

ABSTRACT: The subcellular localization of specific mRNAs is an evolutionary conserved mechanism that underlies the establishment of cellular polarity and specialized cell functions. In neurons, mRNA trafficking and local protein translation in dendrites provides an important mechanism that mediates synaptic development and plasticity. The significance of mRNA targeting and protein synthesis in axons, however, is still unclear. Only a small number of transcripts have been identified in axons to date, and their contribution to axon growth and neuronal survival remains largely unknown. Here, we report the results of a novel screen that allowed the separate identification of mRNAs localized in cell bodies and in axons of developing neurons. Using compartmentalized cultures of sympathetic neurons and

ORGANISM(S): Rattus norvegicus

SUBMITTER: Catia Andreassi 

PROVIDER: E-GEOD-13788 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress