Gene expression profiling of 22 inbred parental strains

ABSTRACT: The remarkable success observed in using genome-wide association (GWA) mapping in human cohorts to identify multiple genes linked to a wide number of traits related to complex diseases has renewed interest in applying genome-wide association mapping techniques to model organisms such as inbred laboratory mice. However, unlike humans, the limited genetic diversity present in the ancestry of laboratory mice combined with intense selection pressure over the past decades have yielded an intricate population structure within the genomes of laboratory mouse that could potentially complicate the results obtained from such a study. We sought to empirically assess the viability of genome-wide association studies in inbred mice using hundreds of expression traits where the true location of the eQT

ORGANISM(S): Mus musculus

SUBMITTER: Wan-Lin Su 

PROVIDER: E-GEOD-13870 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress