Diabetic Microangiopathy in the Bone Marrow Causes Hypoperfusion and Depletion of the Stem Cell Niche.

ABSTRACT: Diabetes mellitus [DM], with its burden of premature morbidity and mortality, represents one of the major threats to human health in the 21st century (Zimmet 2001). Accelerated atherosclerosis affecting arteries that supply the heart, brain and lower extremities is responsible for an increased risk of acute ischemic events. DM is also associated with microvascular disease, which is a leading cause of blindness, renal failure and debilitating neuropathies. Endothelial dysfunction, increased vascular permeability and microvascular cell loss by apoptosis are all hallmarks of diabetic microangiopathy. Diabetic patients not only incur cardiovascular complications more frequently, but also experience worse outcomes due to attenuation of vascular repair mechanisms. This impairment includes quanti

ORGANISM(S): Mus musculus

SUBMITTER: Anton Horrevoets 

PROVIDER: E-GEOD-14035 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress