Mitochondrial dysfunction in Arabidopsis thaliana.

ABSTRACT: We characterized the global response of plants carrying a mitochondrial dysfunction induced by the expression of the unedited form of the ATP synthase 9 subunit. The u-ATP9 transgene driven by A9 and Apetala3 promoters induce mitochondrial dysfunction revealed by a decrease in both oxygen uptake and ATP levels, with an increase in ROS and a concomitant oxidative stress response. The transcriptome analysis of young Arabidopsis flowers, validated by RT-PCR and enzymatic or functional tests, show dramatic changes in u-ATP9 plants. Both lines present a modification in the expression of several genes involved in carbon, lipid and cell wall metabolism, suggesting that an important metabolic readjustment occurs in plants with a mitochondrial dysfunction. Interestingly, transcript levels involved

ORGANISM(S): Arabidopsis thaliana

SUBMITTER: Paula Casati 

PROVIDER: E-GEOD-14240 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress