Transcription profiling of S. pombe to investigate genetic control of cellular quiescence

ABSTRACT: Transition from proliferation to quiescence brings about extensive changes in cellular behavior and structure. However, genes critical for establishing and/or for maintaining quiescence are largely unknown. The fission yeast S. pombe is found as an excellent model for studying this problem, because it becomes quiescent under nitrogen starvation. Here we characterize 610 temperature-sensitive (ts) mutants, and identify 33 genes required for entry into and the maintenance of quiescence. These genes cover a broad range of cellular functions in the cytoplasm, membrane and the nucleus, encoding proteins for stress-responsive and cell cycle kinase signaling pathway, actin-bound and osmo-controlling endosome formation, RNA transcription, splicing and ribosome biogenesis, chromatin silencing, bios

ORGANISM(S): Schizosaccharomyces pombe

SUBMITTER: Kenichi Sajiki 

PROVIDER: E-GEOD-14319 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress