Distinctive responses to nitrogen starvation in the dominant active mutants of the fission yeast Rheb GTPase.
Ontology highlight
ABSTRACT:
ORGANISM(S): Schizosaccharomyces pombe
SUBMITTER: Yuji Chikashige
PROVIDER: E-GEOD-14626 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Distinctive responses to nitrogen starvation in the dominant active mutants of the fission yeast Rheb GTPase.
Murai Tomoka T Nakase Yukiko Y Fukuda Keiko K Chikashige Yuji Y Tsutsumi Chihiro C Hiraoka Yasushi Y Matsumoto Tomohiro T
Genetics 20090720 2
Rheb, a Ras-like small GTPase conserved from human to yeast, controls Tor kinase and plays a central role in the regulation of cell growth depending on extracellular conditions. Rhb1 (a fission yeast homolog of Rheb) regulates amino acid uptake as well as response to nitrogen starvation. In this study, we generated two mutants, rhb1-DA4 and rhb1-DA8, and characterized them genetically. The V17A mutation within the G1 box defined for the Ras-like GTPases was responsible for rhb1-DA4 and Q52R I76F ...[more]
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