Compartmental Localization and Clinical Relevance of MICA Antibodies after Renal Transplantation

ABSTRACT: Background: Studies recently support that non-HLA antigens could be additional targets of injury in organ transplant recipients, and MICA was associated with an increased risk of graft loss. Methods: A ProtoArray platform was used to study 37 serum samples from 22 unique patients (15 renal recipients and 7 healthy controls). Thirty paired pre- and post-transplant serum samples were analyzed for detection of de novo post-transplant antibody responses in the 15 patients (10 acute rejection (AR), 5 Stable). Probes on ProtoArray and cDNA platforms (GSE: 3931) were re-annotated and compartment specific gene lists were analyzed using the integrated genomics method. Normal and transplant kidney IHC were performed for MICA antigen localization. Results: Mean MICA-Ab (antibody) signal intensity w

ORGANISM(S): Homo sapiens

SUBMITTER: Neeraja Kambham 

PROVIDER: E-GEOD-14329 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress