Identifying Compartment-specific Alloimmune Targets After Renal Transplantation by integrated genomics

ABSTRACT: Microarray technology has evolved as a powerful tool over the last decade, to identify biomarkers and study the mechanisms of diseases. We propose a novel application of integrated genomics by combining transcriptional levels with serological antibody profiling after kidney transplantation, with the aim of uncovering the relative immunogenicity of seven different renal compartments after allo-transplantation. Thirty-six paired pre- and post-transplant serum samples were examined from eighteen transplant recipients, across 5,056 protein targets on the ProtoArray V3.0 platform. Normal renal compartment-specific gene expression data from a cDNA platform were re-analyzed and both the cDNA and the ProtoArray platforms were re-annotated to most up-to-date NCBI gene identifiers; 3,835 genes/prote

ORGANISM(S): Homo sapiens

SUBMITTER: Neeraja Kambham 

PROVIDER: E-GEOD-10452 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress