The Genetic Regulation of the Terminating Phase of Liver Regeneration

ABSTRACT: The liver regeneration process terminates when the normal liver-mass/body-weight ratio of 2.5 % has been re-established. We aimed to generate and analyse global expression profiles to study the genetic interactions in relation to liver regeneration, to illuminate the genetic interactions between genes regulating the cell cycle and apoptosis, and to clarify the role of TGF-M-CM-^_ signalling in the terminating phase of liver regeneration. Twelve pigs were randomised to either 60% liver resection (n=4), sham operation (n=4) or control animals (n=4). Liver biopsies were taken at time of resection, after three weeks and upon termination the sixth week. Global gene expression profiles in the biopsies were obtained using porcine oligonucleotide microarrays, representing approximately 20000 porci

ORGANISM(S): Sus scrofa

SUBMITTER: Jakob Hedegaard 

PROVIDER: E-GEOD-14396 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress