Transcription profiling of mouse Oli-neu cells as they differentiate into myelin basic protein-producing cells after treatment with three different agents

ABSTRACT: Inadequate remyelination of brain white matter lesions has been associated with a failure of oligodendrocyte precursors to differentiate into mature, myelin-producing cells. In order to better understand which genes play a specific role in oligodendrocyte differentiation we performed time dependent, genome-wide gene expression studies of mouse Oli-neu cells as they differentiate into myelin basic protein-producing cells, following treatment with three different agents. Our data indicate that different inducers activate distinct pathways that ultimately converge into the differentiated state where regulated gene sets overlap maximally. In order to also gain insight into the functional role of genes that are regulated in this process, we silenced 88 of these genes using siRNA, and identified

ORGANISM(S): Mus musculus

SUBMITTER: Marc Lamarine 

PROVIDER: E-GEOD-14406 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress