Gene expression in b1-integrin wild-type and knockout mouse heart

ABSTRACT: Growth and expansion of ventricular chambers is essential during cardiogenesis and is achieved by proliferation of cardiac progenitors that are not fully differentiated. Disruption of this process can lead to prenatal lethality. In contrast, adult cardiomyocytes achieve growth through hypertrophy rather than hyperplasia. Although epicardial-derived signals may contribute to the proliferative process in myocytes, the factors and cell types responsible for development of the ventricular myocardial thickness are unclear. Moreover, the function of embryonic cardiac fibroblasts, derived from epicardium, and their secreted factors are largely unknown. Using a novel co-culture system, we found that embryonic cardiac fibroblasts induced proliferation of cardiomyocytes, in contrast to adult cardiac

ORGANISM(S): Mus musculus

SUBMITTER: Masaki Ieda 

PROVIDER: E-GEOD-14411 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress