Methylation profiling of differentially expressed regions between C57BL/6 and BALB/c in bone marrow derived macrophages

ABSTRACT: DNA-methylation is a vital epigenetic mark that participates in establishing and maintaining chromatin structures and in regulating gene transcription during mammalian development and cellular differentiation. Inter-individual differences in methylation patterns may represent a major source of phenotypic variation, however, the determinants, inheritance, extent, and consequences of such differences are poorly understood. Here we have analysed methylation profiles of immune cells from two inbreed mouse strains (C57BL/6 & BALB/c) that represent prototypic models for Th1- or Th2-dominated immune responses. Using a methyl-CpG immunoprecipitation approach, genomes were fractionated into methylated and unmethylated genome pools and separately analysed at 180 genomic regions (covering 28 Mb of th

ORGANISM(S): Mus musculus

SUBMITTER: Michael Rehli 

PROVIDER: E-GEOD-14463 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress