LiaR Transcriptome in Streptococcus agalactiae

ABSTRACT: Streptococcus agalactiae (Group B Streptococcus, GBS) is a leading cause of early-onset neonatal bacterial infection. Evasion of innate immune defenses is critical to neonatal GBS disease pathogenesis. Effectors of the innate immune system such as antimicrobial peptides, as well as numerous antibiotics, target the peptidoglycan layer of the gram positive bacterial cell wall. The intramembrane-sensing histidine kinase class of two-component regulatory systems has recently been identified as important to the gram-positive response to cell wall stress. We identified and characterized the GBS homolog of LiaR, the response regulator component of the LiaFSR system and constructed site-directed, non-polar deletion mutations in the regulator gene liaR. GBS LiaR deletion mutant strains are mor

ORGANISM(S): Streptococcus agalactiae

SUBMITTER: Julie Dunning Hotopp 

PROVIDER: E-GEOD-14571 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress