Long intronic non-coding RNA from the KLHL29 locus regulates proliferation of human tumorigenic cell lines

ABSTRACT: Many classes of noncoding RNAs (ncRNAs) are known to be involved in gene expression regulation; however, long intronic ncRNAs have received little attention. In previous works, our group has provided evidence that intronic regions, transcribed from 80% of all RefSeq gene loci, are key sources of potentially regulatory ncRNAs. Intronic transcripts were shown to be correlated to the degree of prostate cancer differentiation, regulated by physiological stimuli, and highly expressed in genomic loci related to transcriptional regulation. In the present work we aimed at functional characterization of KLHL29 intronic transcript, one of the most highly expressed in human tissues. Although the protein-coding KLHL29 transcripts are still poorly studied, genes from this family are involved in a wide

ORGANISM(S): Homo sapiens

SUBMITTER: Rodrigo Louro 

PROVIDER: E-GEOD-14681 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress