Woman skeletal muscle transcriptome with bed rest and countermeasures.

ABSTRACT: Microgravity has a dramatic impact on human physiology, illustrated in particular with skeletal muscle impairment. A thorough understanding of the mechanisms leading to loss of muscle mass and structural disorders is necessary for the definition of efficient clinical and spaceflight countermeasures. We investigated the effects of long-term bed rest on transcriptome of soleus (SOL) and vastus lateralis (VL) muscles in healthy women (BRC group, n=8), and the potential beneficial impact of protein supplementation (BRN group, n=8) and of a combined resistance and aerobic training (BRE group, n=8). Gene expression profiles were obtained using an in-house made microarray containing 6681 muscles-relevant genes. A two-class statistical analysis was applied on the 2103 genes with consolidated expre

ORGANISM(S): Homo sapiens

SUBMITTER: Angele CHOPARD 

PROVIDER: E-GEOD-14798 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress