Positioning of Necrotic Lobular Intraepithelial Neoplasias within the sequence of breast carcinoma progression

ABSTRACT: Lobular intraepithelial neoplasia grade 3 (LIN) is a recently recognized variant of intraepithelial lobular neoplasia of the breast composed of either uniform, generally small, cells (classic) with massive lobular distension, pleomorphic cells, signet-ring cells, or any cell type with necrosis. In contrast to classic forms of LIN, there is no consensus on therapeutic strategies for LIN3. In part this is due to the paucity of molecular data that could assist in defining the relationship of LIN3 to classic LIN and carcinomas. In this study we have employed array CGH to determine the patterns of chromosomal aberrations in 9 LIN3 lesions. By comparison to array CGH data of 13 classic LIN lesions, we demonstrate that LIN and LIN3 share several recurrent changes, in particular gains of 1q and l

ORGANISM(S): Homo sapiens

SUBMITTER: Reinhard Ullmann 

PROVIDER: E-GEOD-14803 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress