Array CGH in congenital heart disease
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Fikret Erdogan
PROVIDER: E-GEOD-7527 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
High frequency of submicroscopic genomic aberrations detected by tiling path array comparative genome hybridisation in patients with isolated congenital heart disease.
Erdogan F F Larsen L A LA Zhang L L Tümer Z Z Tommerup N N Chen W W Jacobsen J R JR Schubert M M Jurkatis J J Tzschach A A Ropers H-H HH Ullmann R R
Journal of medical genetics 20080819 11
<h4>Background</h4>Congenital heart disease (CHD) is the most common birth defect and affects nearly 1% of newborns. The aetiology of CHD is largely unknown and only a small percentage can be assigned to environmental risk factors such as maternal diseases or exposure to mutagenic agents during pregnancy. Chromosomal imbalances have been identified in many forms of syndromic CHD, but very little is known about the impact of DNA copy number changes in non-syndromic CHD.<h4>Method</h4>A sub-megaba ...[more]
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