Neonatal starvation response and developmental changes in gene expression revealed by hypothalamic expression profiling

ABSTRACT: We performed gene expression microarray analysis of the hypothalamic response to starvation in neonatal wild-type mice, and in Snord116del mice that are a mouse model for PWS. This study is motivated by the neonatal feeding problems observed in several genetic diseases including Prader-Willi syndrome (PWS). Later in life, individuals with PWS develop hyperphagia and obesity due to lack of appetite control. We hypothesize that failure to thrive in infancy and later-onset hyperphagia may be related and could be due to a defect in the hypothalamus. In this study, we performed gene expression microarray analysis of the hypothalamic response to starvation in neonatal wild-type mice, and in Snord116del mice that are a mouse model for PWS. The neonatal starvation response was dramatically differ

ORGANISM(S): Mus musculus

SUBMITTER: Feng Ding 

PROVIDER: E-GEOD-14984 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress