Transcription profiling of human patients with chronic kidney disease

ABSTRACT: Several reports have focused on the identification of biological elements involved in the development of abnormal systemic biochemical alterations in chronic kidney disease, but this abundant literature results most of the time fragmented. To better define the cellular machinery associated to this condition, we employed an innovative high-throughput approach based on a whole transcriptomic analysis and classical biomolecular methodologies. The genomic screening of peripheral blood mononuclear cells revealed that 44 genes were up-regulated in both chronic kidney disease patients in conservative treatment (CKD, n=9) and hemodialysis (HD, n=17) compared to healthy subjects (NORM) (p<0.001, FDR=1%). Functional analysis demonstrated that 11/44 genes were involved in the oxidative phosphorylatio

ORGANISM(S): Homo sapiens

SUBMITTER: Paola Pontrelli 

PROVIDER: E-GEOD-15072 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress