Temporal pattern of skeletal muscle gene expression following endurance exercise in Alaskan sled dogs

ABSTRACT: Background: Muscle responses to exercise are complex, and potentially include acute responses to exercise-induced injury as well as longer-term adaptive training responses. Using Alaskan sled dogs as an experimental model, changes in muscle gene expression were analyzed to better understand the temporal changes that occur after severe exercise. Methods: Dogs were randomly assigned to undertake in a 160 km run (n=9), or to remain at rest (n=4). Biceps femoris muscle was obtained by needle biopsy from the unexercised dogs and two dogs at each of 2, 6 and 12 hours after the exercise and from 3 dogs 24 hours after exercise. RNA was extracted and microarray analysis used to define gene transcriptional changes. Results: Nine hundred sixty three transcripts exhibited statistically significant

ORGANISM(S): Canis lupus familiaris

SUBMITTER: Olivia Fong 

PROVIDER: E-GEOD-15117 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress