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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Massively Parallel Sequencing Identifies the MicroRNA Transcriptome of Normal and Malignant Human B cells

ABSTRACT: Profiling of miRNA transcriptome in Human mature B cells from similar populations Profiling of miRNA transcriptome in Human Normal and Malignant B cells, 8 normal samples corresponding to Naïve, Germinal Center, Plasma and Memory B cells and 23 samples derived from B cell malignancy

ORGANISM(S): Homo sapiens

SUBMITTER: Dereje Jima

PROVIDER: E-GEOD-15229 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs.

Jima Dereje D DD Zhang Jenny J Jacobs Cassandra C Richards Kristy L KL Dunphy Cherie H CH Choi William W L WW Au Wing Yan WY Srivastava Gopesh G Czader Magdalena B MB Rizzieri David A DA Lagoo Anand S AS Lugar Patricia L PL Mann Karen P KP Flowers Christopher R CR Bernal-Mizrachi Leon L Naresh Kikkeri N KN Evens Andrew M AM Gordon Leo I LI Luftig Micah M Friedman Daphne R DR Weinberg J Brice JB Thompson Michael A MA Gill Javed I JI Liu Qingquan Q How Tam T Grubor Vladimir V Gao Yuan Y Patel Amee A Wu Han H Zhu Jun J Blobe Gerard C GC Lipsky Peter E PE Chadburn Amy A Dave Sandeep S SS

Blood 20100823 23

A role for microRNA (miRNA) has been recognized in nearly every biologic system examined thus far. A complete delineation of their role must be preceded by the identification of all miRNAs present in any system. We elucidated the complete small RNA transcriptome of normal and malignant B cells through deep sequencing of 31 normal and malignant human B-cell samples that comprise the spectrum of B-cell differentiation and common malignant phenotypes. We identified the expression of 333 known miRNA ...[more]

PMID: 20733160

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Deep Sequencing of the Small RNA Transcriptome of Normal and Malignant Human B cells Identifies Hundreds of Novel MicroRNAs

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