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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Expression data from A2780 (cisplatin-sensitive) and Round5 A2780 (cisplatin-resistant) cell lines.

ABSTRACT: Cisplatin and carboplatin are the primary first-line therapies for the treatment of ovarian cancer. However, resistance to these platinum-based drugs occurs in the large majority of initially responsive tumors, subsequently resulting in a poor long-term prognosis. To model the onset of drug resistance, we measured gene expression alterations associated with cisplatin resistance. We treated clonally derived, drug-sensitive A2780 epithelial ovarian cancer cells with increasing concentrations of cisplatin. After 5 cycles of drug selection, the isogenic drug-sensitive (parental A2780) and -resistant (Round5 A2780) cell lines were subjected to mRNA expression microarray analyses.

ORGANISM(S): Homo sapiens

SUBMITTER: Meng Li

PROVIDER: E-GEOD-15372 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Integrated analysis of DNA methylation and gene expression reveals specific signaling pathways associated with platinum resistance in ovarian cancer.

Li Meng M Balch Curt C Montgomery John S JS Jeong Mikyoung M Chung Jae Hoon JH Yan Pearlly P Huang Tim H M TH Kim Sun S Nephew Kenneth P KP

BMC medical genomics 20090608

<h4>Background</h4>Cisplatin and carboplatin are the primary first-line therapies for the treatment of ovarian cancer. However, resistance to these platinum-based drugs occurs in the large majority of initially responsive tumors, resulting in fully chemoresistant, fatal disease. Although the precise mechanism(s) underlying the development of platinum resistance in late-stage ovarian cancer patients currently remains unknown, CpG-island (CGI) methylation, a phenomenon strongly associated with abe ...[more]

PMID: 19505326

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